Crystal Structure of 6-(o-Chlorophenyl)-8-ethyl-1-methyl-4H-s-triazo(3,4-c)thieno(2,3-e)(l,4)diazepine (Etizolam).
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چکیده
منابع مشابه
Crystal structure of (2S,4R)-ethyl 4-nitromethyl-1-[(S)-1-phenylethyl]-6-sulfanylidenepiperidine-2-carboxylate
In the title compound, C17H22N2O4S, a thio-piperidine derivative, the piperidine ring has an envelope conformation with the methyl-ene C atom opposite to the C=S bond as the flap. The nitro-methyl substituent is equatorial while the eth-oxy-carbonyl group is axial. The mean planes of the nitro-methyl group, the carb-oxy group and phenyl ring are inclined to the mean plane through the five plana...
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The title compound, C20H27ClN2O3, was obtained via an original synthesis method. The central heterocyclic ring adopts a shallow envelope conformation, with the N atom bearing the cyclo-pentane ring as the flap [deviation from the other atoms = 0.442 (2) Å]. The cyclo-pentane ring adopts a twisted conformation about one of the CN-C bonds: the exocyclic C-N bond adopts an equatorial orientation. ...
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The benzodiazepines (BZs) are the most widely used hypnotics. The thienobenzodiazepine derivative etizolam, 6-(o-chlorophenyl)-8ethyl-1-methyl-4H-s-triazolo[3,4-c]thieno[2,3-e] [1,4]diazepine, is a comparatively new potent anxiolytic and/or hypnotic [1]. The BZs have been considered largely free of neuro-endocrine effect [2]. However, hyperprolactinemia and galactorrhea have been suggested to b...
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Department of Disease Glycomics, Research Institute for Microbial Diseases, Osaka University, Taniguchi Research Group, 4th Flr, Center for Advanced Science & Innovation, Osaka University, 2-1, Yamadaoka Suita, Osaka 565-0871, Japan Division of Molecular Cell Biology, Department of Biomolecular, Sciences, Saga University Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan CREST, JST Graduate ...
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In the title mol-ecular complex, [Ni(C3H5OS2)2(C5H4BrN)2], the Ni(2+) cation is located on a centre of inversion and has a distorted octa-hedral N2S4 environment defined by two chelating xanthate ligands and two monodentate pyridine ligands. The C-S bond lengths of the thio-carboxyl-ate group are indicative of a delocalized bond and the O-Csp (2) bond is considerably shorter than the O-Csp (3) ...
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ژورنال
عنوان ژورنال: Analytical Sciences
سال: 1999
ISSN: 0910-6340,1348-2246
DOI: 10.2116/analsci.15.407